A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices

نویسندگان

  • Ashley P. Barlow
  • Jane He
  • Cindy Tian
  • Peter Jeffery
  • Stephen C. Mason
  • Bao-Jun Tai
  • Han Jiang
  • Gareth D. Rees
  • Min Quan Du
چکیده

A comparison of the desensitising efficacy of two commercially available dentifrices with different modes of action was conducted in a randomised, examiner-blind, two-arm, parallel group, 8-week, longitudinal clinical study. Dentifrice A, (Sensodyne Multi Action Iso-Active), contained 50000 ppm KNO(3) and 1450 ppm fluoride as NaF. Dentifrice B, Colgate Sensitive Pro-Relief, contained a combination of 80000 ppm arginine, bicarbonate, calcium carbonate, and 1450 ppm fluorine as NaMFP. Subjects (N = 110), stratified into two groups (N = 55), brushed twice-daily for 60 s, over an 8-week period. Sensitivity status, compliance, and safety were determined at 1, 2, 4, and 8 weeks. A fixed-effects ANCOVA statistical model was applied to the Intent-To-Treat population using a two-sided 5% significance level. After 8 weeks, the treatment groups using Dentifrice A and Dentifrice B exhibited mean reductions from baseline of 49% and 45% in air sensitivity visual analogue scale (VAS) score, 61% (both) in examiner-based Schiff Sensitivity score, and clinically significant reductions in tactile pain threshold; all reductions were statistically significant (P < 0.0001). Both treatment groups also exhibited significant reductions across all sensitivity measures at 1, 2, and 4 weeks (P ≤ 0.0059, Dentifrice A; P ≤ 0.0137, Dentifrice B).

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Efficacy of Plaque Control by Tooth Brushing with and without Different Dentifrices: A Clinical Trial

  Objective: Microbial plaque is among the main etiologies of periodontal disease, and tooth brushing with toothpaste is the most commonly used method of plaque control. This study aimed to compare the efficacy of tooth brushing with and without three different dentifrices.   Methods: Thirty dental students were randomly selected to participate in this clinical trial and were asked to refrain f...

متن کامل

Comparative Evaluation of the Fluoride Recharge Ability of Two Glass Ionomers Obtained from Fluoridated Dentifrice and CPP-ACFP Paste: An In-vitro Study

Introduction: Glass ionomer cement (GIC) is a restorative material used in pediatric dentistry, which attaches to dental hard tissues and has cariostatic properties due to the ability for fluoride release. The present study aimed to assess the fluoride release and uptake capacity of two GICs in the presence of various fluoride sources. Methods: This in-vitro study was conducted on 120 disks com...

متن کامل

Comparative Evaluation of the Efficacy of Wisdom and Inspiration in Abu Hatam’s and Zakariyya Razi’s Opinions

The question has always been raised throughout history whether human beings need to follow the prophets or divine revelation to achieve salvation. There will be no need, as some believe, to follow divine teachings once human beings reach intellectual maturity; however, others insist on the permanent need for Guidance from God due to inadequacy of human reason. In the third or fourth century AH,...

متن کامل

Comparative evaluation of the antimicrobial efficacy of aloe vera tooth gel and two popular commercial toothpastes: an in vitro study.

Aloe vera (Aloe barbadensis Miller) has been suggested for a wide variety of ailments but its use in dentistry is limited. This article reviews the uses of the plant and describes an in vitro investigation that compared the antimicrobial effectiveness of aloe vera tooth gel with two popular, commercially available dentifrices. The preliminary results showed that aloe vera tooth gel and the toot...

متن کامل

Comparative study between two treatment regimens of Cisplatin-5-Fluorouracil and Gemcitabine-Cisplatin in gallbladder cancer patients

The research study was designed to compare the safety and efficacy of the regimen of 5-flurouracil with cisplatin of investigational arm with the reference regimen of gemcitabine with cisplatin for the treatment of gallbladder cancer. A total of 60 patients were enrolled in the study. Out of 30 patients enrolled in arm-A (Gemcitabine with Cisplatin) and 30 patients enrolled in arm-B (5-Fluroura...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 2012  شماره 

صفحات  -

تاریخ انتشار 2012